DOI: 10.1002/ame2.12251
To unwind the biological knots: The DNA / RNA G- quadruplex resolvase RHAU ( DHX36 ) in development and disease
Chensi Yang
Jie Yao
Huijuan Yi
Xinyi Huang
Wukui Zhao
Zhongzhou Yang
State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine , Nanjing University Medical School , Nanjing , China
摘要：The G- quadruplex (G4) sequences are short fragments of 4- interval triple guanine (G) with frequent and ubiquitous distribution in the genome and RNA transcripts. The G4 sequences are usually folded into secondary "knot" structure via Hoogsteen hydrogen bond to exert negative regulation on a variety of biological processes, including DNA replication and transcription, mRNA translation, and telomere maintenance. Recent structural biological and mouse genetics studies have demonstrated that RHAU (DHX36) can bind and unwind the G4 "knots" to modulate embryonic development and postnatal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis, and organ dysfunction. These studies uncovered the pivotal G4 resolvase function of RHAU to release the G4 barrier, which plays fundamental roles in development and physiological homeostasis. This review discusses the latest advancements and findings in deciphering RHAU functions using animal models.
机标关键词：developmentbiologicaldiseaseknotsquadruplexresolvaserhauunwind
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 542-549 )
英文信息