DOI: 10.1002/ame2.12229
Autophagy and autophagy- related molecules in neurodegenerative diseases
Changsong Dou
Yu Zhang
Ling Zhang
Chuan Qin
NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Human Diseases Animal Model,Institute of Laboratory Animal Sciences,Comparative Medicine Center,Peking Union Medical College(PUMC),Chinese Academy of Medical Sciences(CAMS),Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing,Comparative Medicine Center,Peking Union Medical College(PUMC),Chinese Academy of Medical Sciences(CAMS),Beijing,China
摘要：Autophagy is one of the degradation pathways to remove proteins or damaged or-ganelles in cells that plays an important role in neuroprotection. Different stages of autophagy are regulated by autophagy- related genes, and many molecules such as transcription factor EB (TFEB) are involved. The complete autophagy process plays an important role in maintaining the dynamic balance of autophagy and is crucial to the homeostasis of intracellular substance and energy metabolism. Autophagy balance is disrupted in neurodegenerative diseases, accounting for a variety of degeneration dis-orders. These impairments can be alleviated or treated by the regulation of autophagy through molecules such as TFEB.
机标关键词：neurodautophagy-degenerativediseasesmoleculesrelated
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 10-17 )
英文信息