DOI: 10.1002/ame2.12301
Blood coagulation factors and platelet response to drug- induced hepatitis and hepatosis in rats
Daria Korolova1
Viktoriya Gryshchenko2
Tamara Chernyshenko1
Oleh Platonov1
Olha Hornytska1
Volodymyr Chernyshenko1
Pavlo Klymenko3
Yevdokiia Reshetnik4
Tetyana Platonova1
1.Department of Structure and function of proteins,Palladin Institute of Biochemistry of NAS of Ukraine,Kyiv,Ukraine2.National University of Life and Environmental Sciences of Ukraine,Kyiv,Ukraine3.SI"D.F.Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine,",Kyiv,Ukraine4.Taras Shevchenko National University of Kyiv,Kyiv,Ukraine
摘要：Background : Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects. The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-i nduced hepatosis and hepatitis in rats.Methods : We modeled diclofenac-i nduced hepatitis and tetracycline-i nduced hepa-tosis. Hemostasis response was gauged by measuring fibrinogen, factor X, protein C (PC), and prothrombin in plasma. The decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin index. Platelet reactivity was studied using aggregometry. Results : Both hepatitis and hepatosis decreased the synthesis of fibrinogen, factor X, and prothrombin. However, protein carboxylation was not disrupted in hepatosis but was much impaired in hepatitis. PC decreased in both models as a consequence of its consumption possibly during inflammatory response. Platelet aggregation rate was lower in hepatosis but higher in hepatitis. Conclusions : Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic complications. Its state indicates the disorder's rate and character.
机标关键词：bloodratscoagulationdrug-factorshepatitishepatosisinduced
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 66-73 )
英文信息