DOI: 10.1002/ame2.12300
The bioelectrical properties of bone tissue
Boon Chin Heng1
Yunyang Bai2
Xiaochan Li2
Yanze Meng3
Yanhui Lu3
Xuehui Zhang4
Xuliang Deng5
1.Department of Dental Materials&Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing,PR China;Central Laboratory,Peking University School and Hospital of Stomatology,Beijing,PR China;School of Medical and Life Sciences,Sunway University,Subang Jaya,Malaysia2.Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,PR China3.Department of Dental Materials&Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing,PR China4.Department of Dental Materials&Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing,PR China;National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,NMPA Key Laboratory for Dental Materials,Beijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing,People's Republic of China5.Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,PR China;National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,NMPA Key Laboratory for Dental Materials,Beijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing,People's Republic of China
摘要：Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell line-ages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular ma-trix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelec-tric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various elec-troactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interac-tive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tis-sue to facilitate bone defect repair.
机标关键词：tissuebioelectricalboneproperties
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 120-130 )
英文信息