DOI: 10.1002/ame2.12315
Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats
Oluwafikemi Temitayo Iji1
Temitayo Olabisi Ajibade2
Oluwaseun Olanrewaju Esan3
Omolola Victoria Awoyomi1
Ademola Adetokunbo Oyagbemi2
Moses Olusola Adetona4
Temidayo Olutayo Omobowale2
Momoh Audu Yakubu5
Oluwafemi Omoniyi Oguntibeju6
Evaristus Nwulia7
1.Federal College of Animal Health and Production Technology,Moor Plantation,Ibadan,Nigeria2.Department of Veterinary Physiology and Biochemistry,Faculty of Veterinary Medicine,University of Ibadan,Ibadan,Nigeria3.Department of Veterinary Medicine,Faculty of Veterinary Medicine,University of Ibadan,Ibadan,Nigeria4.Department of Anatomy,Faculty of Basic Medical Sciences,University of Ibadan,Ibadan,Nigeria5.Department of Environmental and Interdisciplinary Sciences,College of Science,Engineering&Technology,COPHS,Texas Southern University,Houston,Texas,USA6.Department of Biomedical Sciences,Faculty of Health and Wellness Sciences,Cape Peninsula University of Technology,Bellville,South Africa7.Department of Psychiatry and Behavioral Sciences,Howard University Hospital,College of Medicine,Howard University,Washington,District of Columbia,USA
摘要：Background:The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride(CoCI2).This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoCI2 exposure.Methods:Forty-two(42)male rats were grouped as Control;(CoCI2;300ppm);CoCI2+Glycine(50mg/kg);CoCI2+Glycine(100mg/kg);Glycine(50mg/kg);and Glycine(100mg/kg).The markers of hepatic and renal damage,oxidative stress,the antioxidant defense system,histopathology,and immunohistochemical localization of neutrophil gelatinase associated lipocalin(NGAL)and renal podocin were evaluated.Results:Glycine significantly reduced the markers of oxidative stress(malondialde-hyde content and H2O2 generation),liver function tests(ALT,AST,and ALP),markers of renal function(creatinine and BUN),and decreased the expression of neutrophil gelatinase-associated lipocalin(NGAL)and podocin compared with rats exposed to CoCI2 toxicity without glycine treatment.Histopathology lesions including patchy tubular epithelial necrosis,tubular epithelial degeneration and periglomerular inflam-mation in renal tissues,and severe portal hepatocellular necrosis,inflammation,and duct hyperplasia were observed in hepatic tissues of rats exposed to CoCI2 toxicity,but were mild to absent in glycine-treated rats.Conclusion:The results of this study clearly demonstrate protective effects of gly-cine against CoCI2-induced tissue injuries and derangement of physiological activi-ties of the hepatic and renal systems in rats.The protective effects are mediated via augmentation of total antioxidant capacity and upregulation of NGAL and podocin expression.
机标关键词：ratsameliorativechloridecobalteffectsglycinehepato-renalinduced
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 168-177 )
英文信息