DOI: 10.1002/ame2.12306
Era of the 4D animal model
Lihong Zhang
Jindan Guo
Jiangning Liu
NHC Key Laboratory of Human Disease Comparative Medicine,Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing,China
摘要：Revealing the entire dynamics of pathogenesis is critical for understanding,prevent-ing and treating human disease but is limited by systematic clinical sampling.This drawback can be overcome with animal model studies.Recent advances in pheno-typing,omics and bioinformatics technologies promote the development of the 4D animal model to simulate and digitally display the spatiotemporal landscapes of phe-notypes and molecular dynamics in human diseases and reveal novel targets for diag-nosis and therapy.In this commentary,the origin,supporting technologies,content,function and application,and advantages of 4D animal models over clinical studies and traditional animal models,as well as their limitations,are presented.
机标关键词：modelanimal
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 178-182 )
英文信息