DOI: 10.1002/ame2.12333
Combination of Shengmai San and Radix puerariae ameliorates depression-like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression
Ayaz Ahmed1
Guirong Zeng2
Mudassar Azhar3
Fengzhong Wang4
Jingru Wang5
Bei Fan4
Xinmin Liu6
Dejiang Jiang7
Qiong Wang8
1.Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China;Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs & Hunan Provincial Research Center for Safety Evaluation of Drugs,Changsha,China;Dr.Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi,Karachi,Pakistan2.Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs & Hunan Provincial Research Center for Safety Evaluation of Drugs,Changsha,China;institute of Drug Discovery Technology,Ningbo University,Ningbo,China;Research Center for Pharmacodynamic,Material Basis and Mechanism of Action,College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,China3.Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs & Hunan Provincial Research Center for Safety Evaluation of Drugs,Changsha,China;Dr.Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi,Karachi,Pakistan4.Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China5.Research Center for Pharmacodynamic,Material Basis and Mechanism of Action,College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,China6.Dr.Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi,Karachi,Pakistan;institute of Drug Discovery Technology,Ningbo University,Ningbo,China7.Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs & Hunan Provincial Research Center for Safety Evaluation of Drugs,Changsha,China8.Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China;Sino-Portugal TCM International Cooperation Center,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,China
摘要：Background:Hyperglycemia is a characteristic feature of diabetes that often results in neuropsychological complications such as depression.Diabetic individuals are more vulnerable to experience depression compared to the normal population.Thus,novel treatment approaches are required to reduce depressive symptoms among diabetic individuals.Traditional Chinese medicines(TCMs)such as Shengmai San(SMS)and Radix puerariae(R)are usually widely used to treat ailments such as neurological com-plications since ancient time.Methods:In this study,SMS was combined with R to prepare an R-SMS formulation and screened for their antidepressant activity in diabetic rats.The antidepressant po-tential of the prepared combination was evaluated behaviorally using open field test,novelty-induced hypophagia,and forced swim test in diabetic rats with biochemical and protein expression(PI3K,BDNF[brain-derived neurotrophic factor],and SYN[pr-esynaptic vesicle protein])analysis.Results:Diabetic rats(streptozotocin,45mg/kg)showed elevated fasting blood glu-cose(FBG)＞12 mM with depressive symptoms throughout the study.Treatment with R-SMS(0.5,1.5,and 4.5g/kg)significantly reverted depressive symptoms in diabetic rats as evinced by significantly(p＜0.05)reduced immobility time with an increased tendency to eat food in a novel environment.Treatment with R-SMS also significantly increased the protein expression of PI3K,BDNF,and SYN protein,which play a crucial role in depression.Conclusion:This study showed that R-SMS formulation antagonized depressive symptoms in diabetic rats;thus,this formulation might be studied further to develop as an antidepressant.
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论文发表日期：2023-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 211-220 )
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