DOI: 10.1002/ame2.12323
Zataria multiflora and its constituent,carvacrol,counteract sepsis-induced aortic and cardiac toxicity in rat:Involvement of nitric oxide and oxidative stress
Mahmoud Hosseini1
Zohreh Arab2
Farimah Beheshti3
Akbar Anaeigoudari4
Farzaneh Shakeri5
Arezoo Rajabian6
1.Psychiatry and Behavioral Sciences Research Center,Mashhad University of Medical Sciences,Mashhad,Iran2.Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran3.Neuroscience Research Center,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran;Department of Physiology,School of Paramedical Sciences,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran4.Department of Physiology,School of Medicine,Jiroft University of Medical Sciences,Jiroft,Iran5.Natural Products and Medicinal Plants Research Center,North Khorasan University of Medical Sciences,Bojnurd,Iran;Department of Physiology and Pharmacology,School of Medicine,North Khorasan University of Medical Sciences,Bojnurd,Iran6.Department of Internal Medicine,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran
摘要：Background:Zataria multiflora and carvacrol showed various pharmacological prop-erties including anti-inflammatory and anti-oxidant effects.However,up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury.Thus,this study aimed to investigate the effects of Z.multiflora and carvacrol on nitric oxide(NO)and oxidative stress indicators in lipopolysaccharide(LPS)-induced aortic and cardiac injury.Methods:Adult male Wistar rats were assigned to:Control,lipopolysaccharide(LPS)(1mg/kg,intraperitoneal(i.p.)),and Z.multiflora hydro-ethanolic extract(ZME,50-200mg/kg,oral)-and carvacrol(25-100mg/kg,oral)-treated groups.LPS was in-jected daily for 14days.Treatment with ZME and carvacrol started 3days before LPS administration and treatment continued during LPS administration.At the end of the study,the levels of malondialdehyde(MDA),NO,thiols,and antioxidant enzymes were evaluated.Results:Our findings showed a significant reduction in the levels of superoxide dis-mutase(SOD),catalase(CAT),and thiols in the LPS group,which were restored by ZME and carvacrol.Furthermore,ZME and carvacrol decreased MDA and NO in car-diac and aortic tissues of LPS-injected rats.Conclusions:The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO pro-duction.However,additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.
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论文发表日期：2023-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 221-229 )
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