DOI: 10.1002/ame2.12328
Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat
Shuaiyang Liu1
Yun Chen2
Xiaoming Wang1
Shuang Wang3
Lan Bai4
Xu Cheng4
Juan Wan4
Yufeng Hu4
Yi Ding3
Xin Zhang4
Mingxing Ding3
Hongliang Li5
Manli Hu4
1.School of Basic Medical Science,Wuhan University,Wuhan,China;Institute of Model Animal,Wuhan University,Wuhan,China2.Institute of Model Animal,Wuhan University,Wuhan,China;Clinical Trial Centers,Huanggang Central Hospital,Huanggang,China3.College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,China4.Key Laboratory of Cardiovascular Disease Prevention and Control,Ministry of Education,School of Basic Medical Science,Gannan Medical University,Ganzhou,China;Gannan Innovation and Translational Medicine Research Institute,Gannan Medical University,Ganzhou,China5.School of Basic Medical Science,Wuhan University,Wuhan,China;Institute of Model Animal,Wuhan University,Wuhan,China;Gannan Innovation and Translational Medicine Research Institute,Gannan Medical University,Ganzhou,China
摘要：Background:The purpose of our study was to study the composition and content of the feline plasma metabolome revealing the critical metabolites and metabolic path-ways associated with age during growth and development.Methods:Blood samples were collected from juvenile and adult groups for blood rou-tine tests and serum biochemistry tests.Non-targeted metabolomics analyses of plasma were also performed to investigate changes in metabolites and metabolic pathways.Results:In this study,we found that the red blood cell counts,liver function indexes(albumin and gamma-glutamyl transpeptidase),and the concentration of triglyceride and glucose changed significant with growth and development.The metabolomics results revealed that 1427 metabolites were identified in the plasma of young and adult cats.Most of these metabolites belong to major classes of lipids and lipid-like molecules.The most obvious age-related metabolites include reduced levels of che-nodeoxycholate,taurocholate,cholate,and taurochenodeoxycholate but increased levels of L-cysteine and taurocyamine in the adult cat's serum.These metabolites are mainly involved in the primary bile acid biosynthesis pathway,the bile secretion path-way,and the taurine and hypotaurine metabolism pathway.Conclusion:This study revealed many age-related metabolite alterations in the feline plasma.These age-varying metabolites,especially in the bile acid biosynthesis and secretion metabolism pathways,indicate that the regulation of these pathways is in-volved in the growth and development of cats.This study promotes our understand-ing of the mechanism of feline growth and provides new insights into nutrition and medicine for cats of different ages.
机标关键词：metabolicdevelopmentplasmagrowthwithalterationsassociatedidentifies
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 306-316 )
英文信息