DOI: 10.1002/ame2.12334
Biology and function of pericytes in the vascular microcirculation
Yue Wu1
Jiaqi Fu2
Yuxia Huang3
Ruowang Duan4
Wentian Zhang5
Caihong Wang6
Shang Wang3
Xiaoyi Hu3
Hui Zhao6
Lan Wang3
Jinming Liu3
Guosheng Gao7
Ping Yuan3
1.Ningbo University School of Medicine,Ningbo,China;Department of Clinical Laboratory,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China2.Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China;Institute of Health Science and Engineering,University of Shanghai Science and Technology,Shanghai,China3.Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China4.Department of Anesthesiology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China5.Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai,China6.Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China;Institute of Bismuth Science,University of Shanghai for Science and Technology,Shanghai,China7.Ningbo Huamei Hospital,University of Chinese Academy of Sciences,Ningbo,China
摘要：Pericytes are the main cellular components of tiny arteries and capillaries.Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines,thus affecting the contraction and relaxation of microves-sels and playing an essential role in regulating vascular microcirculation.Moreover,due to the characteristics of stem cells,pericytes can differentiate into a variety of inflammatory cell phenotypes,which then affect the immune function.Additionally,pericytes can also participate in angiogenesis and wound healing by interacting with endothelial cells in vascular microcirculation disorders.Here we review the origin,biological phenotype and function of pericytes,and discuss the potential mechanisms of pericytes in vascular microcirculation disorders,especially in pulmonary hyperten-sion,so as to provide a sound basis and direction for the prevention and treatment of vascular microcirculation diseases.
机标关键词：biologyfunctionmicrocirculationpericytesvascular
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 337-345 )
英文信息