DOI: 10.1002/ame2.12349
Progress in building clinically relevant patient-derived tumor xenograft models for cancer research
Weijing Wang1
Yongshu Li2
Kaida Lin1
Xiaokang Wang3
Yanyang Tu4
Zhenjian Zhuo5
1.Department of Clinical Medicine,Shantou University Medical College,Shantou,China2.College of Life Sciences,Hubei Normal University,Huangshi,China;Shenzhen Institute for Technology Innovation,National Institute of Metrology,Shenzhen,China3.Department of Pharmacy,Shenzhen Longhua District Central Hospital,Shenzhen,China4.Research Center,Huizhou Central People's Hospital,Guangdong Medical University,Huizhou City,China5.State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,China;Laboratory Animal Center,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,China
摘要：Patient-derived tumor xenograft(PDX)models,a method involving the surgical ex-traction of tumor tissues from cancer patients and subsequent transplantation into immunodeficient mice,have emerged as a pivotal approach in translational research,particularly in advancing precision medicine.As the first stage of PDX development,the patient-derived orthotopic xenograft(PDOX)models implant tumor tissue in mice in the corresponding anatomical locations of the patient.The PDOX models have sev-eral advantages,including high fidelity to the original tumor,heightened drug sensi-tivity,and an elevated rate of successful transplantation.However,the PDOX models present significant challenges,requiring advanced surgical techniques and resource-intensive imaging technologies,which limit its application.And then,the humanized mouse models,as well as the zebrafish models,were developed.Humanized mouse models contain a human immune environment resembling the tumor and immune sys-tem interplay.The humanized mouse models are a hot topic in PDX model research.Regarding zebrafish patient-derived tumor xenografts(zPDX)and patient-derived or-ganoids(PDO)as promising models for studying cancer and drug discovery,zPDX models are used to transplant tumors into zebrafish as novel personalized medical animal models with the advantage of reducing patient waiting time.PDO models pro-vide a cost-effective approach for drug testing that replicates the in vivo environment and preserves important tumor-related information for patients.The present review highlights the functional characteristics of each new phase of PDX and provides in-sights into the challenges and prospective developments in this rapidly evolving field.
机标关键词：researchbuildingmodelscancertumorclinicallypatient-derivedprogress
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 381-398 )
英文信息