DOI: 10.1002/ame2.12356
Cellular and molecular characteristics of the premetastatic niches
Hongfei Liu1
Guoxin Zhang2
Ran Gao2
1.Department of Otolaryngology,Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing,China;National Human Diseases Animal Model Resource Center,The Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China;NHC Key Laboratory of Human Disease Comparative Medicine,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China2.National Human Diseases Animal Model Resource Center,The Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China;NHC Key Laboratory of Human Disease Comparative Medicine,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China
摘要：The premetastatic niches(PMN)formed by primary tumor-derived molecules regulate distant organs and tissues to further favor tumor colonization.Targeted PMN therapy may prevent tumor metastasis in the early stages,which is becoming increasingly im-portant.At present,there is a lack of in-depth understanding of the cellular and mo-lecular characteristics of the PMN.Here,we summarize current research advances on the cellular and molecular characteristics of the PMN.We emphasize that PMN inter-vention is a potential therapeutic strategy for early prevention of tumor metastasis,which provides a promising basis for future research and clinical application.
机标关键词：characteristicsmolecularcellularnichespremetastatic
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 399-408 )
英文信息