DOI: 10.1002/ame2.12340
A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications
Cody C.Rounds1
Chengyue Li1
Wei Zhou1
Kenneth M.Tichauer1
Jovan G.Brankov2
1.Biomedical Engineering,Illinois Institute of Technology,Chicago,Illinois,USA;Medical Imaging Research Center,Illinois Institute of Technology,Chicago,Illinois,USA2.Biomedical Engineering,Illinois Institute of Technology,Chicago,Illinois,USA;Medical Imaging Research Center,Illinois Institute of Technology,Chicago,Illinois,USA;Electrical and Computer Engineering,Illinois Institute of Technology,Chicago,Illinois,USA
摘要：Background:As mammography X-ray imaging technologies advance and provide el-evated contrast in soft tissues,a need has developed for reliable imaging phantoms for use in system design and component calibration.In advanced imaging modalities such as refraction-based methods,it is critical that developed phantoms capture the biological details seen in clinical precancerous and cancerous cases while minimizing artifacts that may be caused due to phantom production.This work presents the fab-rication of a breast tissue imaging phantom from cadaveric breast tissue suitable for use in both transmission and refraction-enhanced imaging systems.
Methods:Human cancer cell tumors were grown orthotopically in nude athymic mice and implanted into the fixed tissue while maintaining the native tumor/adipose tissue interface.
Results:The resulting human-murine tissue hybrid phantom was mounted on a clear acrylic housing for absorption and refraction X-ray imaging.Digital breast tomosyn-thesis was also performed.
Conclusion:Both attenuation-based imaging and refraction-based imaging of the phantom are presented to confirm the suitability of this phantom's use in both imag-ing modalities.
机标关键词：applicationsphantomimagingtissuecancerbreastcadavericphase-contrast
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 427-432 )
英文信息