DOI: 10.1002/ame2.12345
Animal models for anti-neutrophil cytoplasmic antibody-associated vasculitis:Are current models good enough?
Fei Huang1
Yongman Lv2
Siyang Liu3
Hao Wu4
Qingquan Liu3
1.Department of Geriatrics,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China;Department of General Medicine,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China2.Department of Nephrology,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China;Department of health management center,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China3.Department of Nephrology,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan,China4.Interdisciplinary Sciences Institute,Huazhong Agricultural University,Wuhan,China;State Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,China
摘要：Antineutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis(AAV)is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood vessels.AAV involves multiple organ systems throughout the body.Our knowledge of the pathogenesis of AAV has increased considerably in recent years,involving cellular,molecular and genetic factors.Because of the con-trolled environment with no other confounding factors,animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side effects.However,the complexity and het-erogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in patients.The aim of this review is to overview the current status of animal models for AAV,outline the pros and cons of methods,and propose potential directions for future research.
机标关键词：currentmodelsgoodanimalanti-neutrophilantibodyassociatedcytoplasmic
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 452-463 )
英文信息