DOI: 10.1002/ame2.12354
Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/xylazine anesthesia and the effect of Acanthopanax senticosus extract
Anton Misak1
Marian Grman1
Lenka Tomasova1
Ondrej Makara2
Zuzana Rostakova3
Iveta Waczulikova4
Karol Ondrias1
1.Institute of Clinical and Translational Research,Department of Molecular Physiology,Biomedical Research Center,Slovak Academy of Sciences,Bratislava,Slovak Republic2.Forest Arboretum Liptovsky Hradok,Liptovsky Hradok,Slovak Republic3.Institute of Measurement Science,Department of Theoretical Methods,Slovak Academy of Sciences,Bratislava,Slovak Republic4.Faculty of Mathematics,Physics and Informatics,Comenius University,Bratislava,Slovak Republic
摘要：Background:Information obtained from arterial pulse waveforms(APW)can be useful for characterizing the cardiovascular system.To achieve this,it is necessary to know the detailed characteristics of APWs in different states of an organism,which would allow APW parameters(APW-Ps)to be assigned to particular(patho)physiological conditions.Therefore,our work aimed to characterize 35 APW-Ps in rats under the influence of isoflurane(ISO)and Zoletil/xylazine(ZO/XY)anesthesia and to study the effect of root extract from Acanthopanax senticosus(ASRE)in these anesthetic conditions.
Methods:The right jugular vein of anesthetized rats was cannulated for the adminis-tration of ASRE and the left carotid artery for the detection of APWs from which 35 APW-Ps were evaluated.
Results:We obtained data on 35 APW-Ps,which significantly depended on the anes-thesia,and thus,they characterized the cardiovascular system under these two con-ditions.ASRE transiently modulated all 35 APW-Ps,including a transient decrease in systolic and diastolic blood pressure(BP)and heart rate or increases in pulse BP,d P/d t max,and systolic and diastolic areas.Whereas the transient effects of ASRE were similar,the extract had prolonged disturbing effects on the cardiovascular system in rats under ZO/XY but not under ISO anesthesia.This negative effect can result from the disturbance caused by ZO/XY anesthesia on the cardiovascular system.
Conclusions:We characterized 35 APW-Ps of rats under ISO and ZO/XY anesthesia and found that ASRE contains compounds that can modulate the properties of the cardiovascular system,which significantly depended on the status of the cardiovas-cular system.This should be considered when using ASRE as a nutritional supplement by individuals with cardiovascular problems.
机标关键词：studypulsemodelwaveacanthopanaxanesthesiaarterialcharacterize
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 474-488 )
英文信息