DOI: 10.1002/ame2.12365
CircRNA and ferroptosis in human disease: Insights for new treatments
Ruoyu Liu1
Yun Zhou2
Yongtong Cao2
1.Department of Clinical Laboratory,China-Japan Friendship Hospital (Institute of Clinical Medical Sciences),Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China2.Department of Clinical Laboratory,China-Japan Friendship Hospital,Beijing,China
摘要：Circular RNA (circRNA), classified as a type of non-coding RNA, has gained significant attention in the field of biology due to its distinctive ring structure and functional properties. Recent research has provided evidence that specific circRNAs have the ability to modulate disease progression through diverse mechanisms, one of which is by regulating cellular ferroptosis. Ferroptosis is a form of regulated cell death that is driven by iron dependency and lipid peroxidation, and extensive investigations have revealed a relationship between ferroptosis and disease development. In addition to evidence that both circRNAs and ferroptosis exert critical roles in disease progression, circRNAs have also been shown to actively mediate the process of ferroptosis. The relationship between circRNAs and ferroptosis therefore influences disease progression and offers novel targets for disease treatment. By directly or indirectly modulating the expression of circRNAs that regulate the expression of ferroptosis-related proteins, it may be possible to impact disease progression by promoting or inhibiting ferroptosis. Current research indicates such approaches may hold significant value in a wide variety of common diseases across physiological systems. This review comprehensively summarizes the findings of recent studies investigating the roles of circRNAs in the regulation of ferroptosis in various diseases.
机标关键词：insightsferroptosiscircrnahumandiseasetreatments
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 508-517 )
英文信息