DOI: 10.1002/ame2.12414
Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet-rich plasma(PRP)
Qian Zhang1
Yanan Wang2
Cheng Ran3
Yingmei Zhou4
Zigang Zhao5
Tianhua Xu3
Hongwei Hou6
Yuan Lu4
1.Beijing Life Science Academy,Beijing,China2.Department of Pathology,Affiliated Hospital of Hebei University,Baoding,China3.Department of Otolaryngology,Affiliated Hospital of Hebei University,Baoding,China4.Department of Dermatology,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,China5.Department of Dermatology,Hainan Hospital of PLA General Hospital,Sanya,China6.Beijing Life Science Academy,Beijing,China;Department of Chemical Engineering,Tsinghua University,Beijing,China
摘要：Background:Androgenic alopecia(AGA)is the most common type of hair loss in men,and there are many studies on the treatment of hair loss by platelet-rich plasma(PRP).The human scalp contains a huge microbiome,but its role in the process of hair loss remains unclear,and the relationship between PRP and the microbiome needs further study.Therefore,the purpose of this study was to investigate the effect of PRP treat-ment on scalp microbiota composition.
Methods:We performed PRP treatment on 14 patients with AGA,observed their clin-ical efficacy,and collected scalp swab samples before and after treatment.The scalp microflora of AGA patients before and after treatment was characterized by amplify-ing the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.
Results:The results showed that PRP was effective in the treatment of AGA pa-tients,and the hair growth increased significantly.The results of relative abundance analysis of microbiota showed that after treatment,g_Cutibacterium increased and g_Staphylococcus decreased,which played a stable role in scalp microbiota.In addi-tion,g_Lawsonella decreased,indicating that the scalp oil production decreased after treatment.
Conclusions:The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.
机标关键词：plasmawithtionalopeciaandrogeneticassociatedcharacterdistinct
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 106-113 )
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