DOI: 10.1002/ame2.12389
Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine
Xuyu Song1
Ying Liu2
Siyi Chen2
Lei Zhang3
Huijie Zhang4
Xianhui Shen5
Hang Du5
Rong Sun6
1.Orthopaedic trauma surgery,The Second Hospital of Shandong University,Jinan,Shandong,China2.Academy of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China3.Department of Traditional Chinese Medicine,The Second Hospital of Shandong University,Jinan,Shandong,China4.College of pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,Shandong,China5.The Second Clinical College of Shandong University,Shandong University,Jinan,Shandong,China6.Advanced Medical Research Institute,Shandong University,Jinan,Shandong,China;The Second Hospital of Shandong University,Jinan,Shandong,China
摘要：Background:Knee osteoarthritis(KOA)characterized by degeneration of knee carti-lage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same outcome.Consequently,researchers are interested in studying KOA and require appropriate animal models for basic research.Chinese herbal compounds,which consist of multiple herbs with diverse pharmaco-logical properties,possess characteristics such as multicomponent,multipathway,and multitarget effects.The potential benefits in the treatment of KOA continue to attract attention.
Purpose:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal models.This will help researchers make informed decisions when choos-ing an animal model.
Methods:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms"knee osteoarthritis,""animal mod-els,""traditional Chinese medicine,"and their combinations,primarily including KOA studies published from 2010 to 2023.
Results:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal models.
Conclusion:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of tradi-tional Chinese medicine compounds in the treatment of KOA.
机标关键词：medicinechinesereviewmodelsanimalinterventionkneeosteoarthritis
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 114-126 )
英文信息