DOI: 10.1002/ame2.12391
Animal models of eosinophilic esophagitis,review and perspectives
Dong Li1
Yujia Wei1
Jing Wang2
Bo Wang3
1.Department of Dermatology,Huazhong University of Science and Technology Tongji Medical College Tongji Hospital,Wuhan,China2.Health Management Center,Huazhong University of Science and Technology Tongji Medical College Tongji Hospital,Wuhan,China3.Department of Gastroenterology,Huazhong University of Science and Technology Tongji Medical College Tongji Hospital,Wuhan,China
摘要：Eosinophilic oesophagitis(EoE)is an allergen/immune-mediated chronic esophageal disease characterized by esophageal mucosal eosinophilic infiltration and esophageal dysfunction.Although the disease was originally attributed to a delayed allergic reac-tion to allergens and a Th2-type immune response,the exact pathogenesis is complex,and the efficacy of existing treatments is unsatisfactory.Therefore,the study of the pathophysiological process of EOE has received increasing attention.Animal models have been used extensively to study the molecular mechanism of EOE pathogenesis and also provide a preclinical platform for human clinical intervention studies of novel therapeutic agents.To maximize the use of existing animal models of EOE,it is impor-tant to understand the advantages or limitations of each modeling approach.This paper systematically describes the selection of experimental animals,types of allergens,and methods of sensitization and excitation during the preparation of animal models of EoE.It also discusses the utility and shortcomings of each model with the aim of providing the latest perspectives on EoE models and leading to better choices of animal models.
机标关键词：reviewmodelsanimaleosinophilicesophagitisperspectives
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 127-135 )
英文信息