DOI: 10.1002/ame2.12438
Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents: A narrative review
Maryam Golmohammadi1
Seyed Arash Aghaei Meibodi1
Sulieman Ibraheem Shelash Al-Hawary2
Jitendra Gupta3
Ibrohim B.Sapaev4
Mazin A.A.Najm5
Marim Alwave6
Mozhgan Nazifi7
Mohammadreza Rahmani8
Mohammad Yasin Zamanian9
Gervason Moriasi10
1.School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran2.Department of Business Administration,Business School,Al al-Bayt University,Mafraq,Jordan3.Institute of Pharmaceutical Research,GLA University,Mathura,India4.Tashkent Institute of Irrigation and Agricultural Mechanization Engineers,Tashkent,Uzbekistan;New Uzbekistan University,Tashkent,Uzbekistan5.Pharmaceutical Chemistry Department,College of Pharmacy,Al-Ayen University,Thi-Qar,Iraq6.Medical Technical College,Al-Farahidi University,Baghdad,Iraq7.Department of Neurology,Hamadan University of Medical Sciences,Hamadan,Iran8.Physiology-Pharmacology Research Center,Research Institute of Basic Medical Sciences,Rafsanjan University of Medical Sciences,Rafsanjan,Iran;Department of Physiology and Pharmacology,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,Iran9.Neurophysiology Research Center,Hamadan University of Medical Sciences,Hamadan,Iran;Department of Pharmacology and Toxicology,School of Pharmacy,Hamadan University of Medical Sciences,Hamadan,Iran10.Department of Medical Biochemistry,School of Medicine,College of Health Sciences,Mount Kenya University,Thika,Kenya
摘要：Glaucoma,an irreversible optic neuropathy,primarily affects retinal ganglion cells (RGC) and causes vision loss and blindness.The damage to RGCs in glaucoma oc-curs by various mechanisms,including elevated intraocular pressure,oxidative stress,inflammation,and other neurodegenerative processes.As the disease progresses,the loss of RGCs leads to vision loss.Therefore,protecting RGCs from damage and promoting their survival are important goals in managing glaucoma.In this regard,resveratrol (RES),a polyphenolic phytoalexin,exerts antioxidant effects and slows down the evolution and progression of glaucoma.The present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the retina.Additionally,RES plays protective roles in RGCs by promoting cell growth,reducing apoptosis,and decreasing oxidative stress in H2O2 -exposed RGCs.RES was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen-activated protein kinase signaling pathways.RES could alleviate retinal function impairment by suppressing the hypoxia-inducible factor-1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt pathway.Therefore,RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.
机标关键词：reviewcellseffectsganglionglaucomanarrativeneuroprotectiveresveratrol
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 195-207 )
英文信息