DOI: 10.1002/ame2.12362
The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice
Meng Li1
Panpan Wei2
Kexin Li2
Haole Liu2
Naqash Alam2
Haiwen Hou2
Jie Deng3
Baohui Xu4
Enqi Liu2
Sihai Zhao5
Yankui Li6
1.Laboratory Animal Center,Xi'an Jiaotong University,Xi'an,China;Department of Vascular Surgery,The Second Hospital of Tianjin Medical University,Tianjin,China2.Laboratory Animal Center,Xi'an Jiaotong University,Xi'an,China3.Department of Cardiology,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China4.Department of Vascular Surgery,Stanford University School of Medicine,Stanford,California,USA5.Laboratory Animal Center,Xi'an Jiaotong University,Xi'an,China;Department of Cardiology,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China6.Department of Vascular Surgery,The Second Hospital of Tianjin Medical University,Tianjin,China
摘要：Intimal hyperplasia (IH) is a negative vascular remodeling after arterial injury.IH occasionally occurs in elastase-induced abdominal aortic aneurysm (AAA) mouse models.This study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastase-induced mouse AAA models.The IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were analyzed.Among 42 elastase-induced AAA mouse models,10 mice developed mild IH (24％) and severe IH was found in only 2 mice (5％).The outer diameters of the AAA segments in mice with and without IH did not show significant difference.Both mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH lesions.There was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe IH.However,only a lower numbers of T cells and B cells were found in the IH lesion.Local cell-secreted matrix metalloproteinases (MMP) 2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe lesions.In conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastase-induced mouse AAA model.This will help researchers better understand this model,and optimize it for use in AAA-related research.
机标关键词：characteristicsratemiceabdominalaneurysmsaorticelastaseexperimental
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 388-395 )
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