DOI: 10.1002/ame2.12455
Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus
Xin-Yue Liu1
Han-Wen Zheng2
Feng-Zhong Wang1
Tul-Wahab Atia3
Bei Fan1
Qiong Wang2
1.Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China2.Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China;Sino-Portugal TCM International Cooperation Center,the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,China3.Dr. Panjwani Center for Molecular Medicine and Drug Research,International Center for Chemical and Biological Sciences,University of Karachi,Karachi,Pakistan
摘要：In traditional Chinese medicine (TCM),based on various pathogenic symptoms and the'golden chamber'medical text,Huangdi Neijing,diabetes mellitus falls under the category'collateral disease'.TCM,with its wealth of experience,has been treating diabetes for over two millennia.Different antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique advantages.As well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic drugs.Chinese herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and terpenoids.These active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free radicals.These actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood glucose.Using different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming clearer.Nonetheless,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its constituents.Further research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations.
机标关键词：mechanismmedicinechineseactionstudyindexassessmentdevelopments
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 433-443 )
英文信息