DOI: 10.1002/ame2.12407
Against all odds:The road to success in the development of human immune reconstitution mice
Yixiao Bin1
Jing Ren1
Haowei Zhang2
Tianjiao Zhang3
Peijuan Liu3
Zhiqian Xin3
Haijiao Yang3
Zhuan Feng3
Zhinan Chen3
Hai Zhang3
1.School of Basic Medical Sciences,Shaanxi University of Chinese Medicine,Xianyang,China;Department of Cell Biology,National Translational Science Center for Molecular Medicine,Fourth Military Medical University,Xi'an,China;State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases,Fourth Military Medical University,Xi'an,China2.Department of Occupational &Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment,School of Public Health,Fourth Military Medical University,Xi'an,China3.Department of Cell Biology,National Translational Science Center for Molecular Medicine,Fourth Military Medical University,Xi'an,China;State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases,Fourth Military Medical University,Xi'an,China
摘要：The mouse genome has a high degree of homology with the human genome,and its physiological,biochemical,and developmental regulation mechanisms are similar to those of humans;therefore,mice are widely used as experimental animals.However,it is undeniable that interspecies differences between humans and mice can lead to experimental errors.The differences in the immune system have become an impor-tant factor limiting current immunological research.The application of immunodefi-cient mice provides a possible solution to these problems.By transplanting human immune cells or tissues,such as peripheral blood mononuclear cells or hematopoietic stem cells,into immunodeficient mice,a human immune system can be reconstituted in the mouse body,and the engrafted immune cells can elicit human-specific immune responses.Researchers have been actively exploring the development and differen-tiation conditions of host recipient animals and grafts in order to achieve better im-mune reconstitution.Through genetic engineering methods,immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the grafts.From initially only being able to reconstruct single T lymphocyte lineages,it is now possible to reconstruct lymphoid and myeloid cells,providing important research tools for immunology-related studies.In this review,we compare the differences in immune systems of humans and mice,describe the devel-opment history of human immune reconstitution from the perspectives of immuno-deficient mice and grafts,and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution,aiming to provide important references for im-munological related researches.
机标关键词：developmentsuccesshumanoddsmiceroadagainstimmune
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 460-470 )
英文信息