DOI: 10.1002/ame2.12409
How can we establish animal models of HIV-associated lymphoma?
Qing Xiao1
Liuyue Zhai1
Xiaomei Zhang1
Yi Liu1
Jun Li1
Xiaoqing Xie1
Guofa Xu1
Sanxiu He1
Huihui Fu1
Yifeng Tang1
Fujie Zhang2
Yao Liu1
1.Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Department of Hematology-Oncology,Chongqing University Cancer Hospital,Chongqing,China2.Beijing Ditan Hospital,Capital Medical University,Beijing,China
摘要：Human immunodeficiency virus (HIV) infection is strongly associated with a height-ened incidence of lymphomas.To mirror the natural course of human HIV infection,animal models have been developed.These models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication strategies.However,there are currently no validated in vivo models of HIV-associated lymphoma (HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing knowledge.This re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.
机标关键词：lymphomamodelsanimalestablishhiv-associated
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 484-496 )
英文信息