DOI: 10.1002/ame2.12445
Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer
Wenyan Wang1
Gehong Dong2
Ziguo Yang1
Shaoxiang Li2
Jia Li2
Lin Wang1
Qiang Zhu1
Yuchen Wang3
1.Department of General Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing,China2.Department of Pathology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China3.Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：Background:Triple-negative breast cancer(TNBC),which is so called because of the lack of estrogen receptors(ER),progesterone receptors(PR),and human epidermal growth factor receptor 2(HER2)receptors on the cancer cells,accounts for 10％-15％of all breast cancers.The heterogeneity of the tumor microenvironment is high.However,the role of plasma cells controlling the tumor migration progression in TNBC is still not fully understood.
Methods:We analyzed single-cell RNA sequencing data from five HER2 positive,12 ER positive/PR positive,and nine TNBC samples.The potential targets were validated by immunohistochemistry.
Results:Plasma cells were enriched in TNBC samples,which was consistent with validation using data from The Cancer Genome Atlas.Cell communication analysis revealed that plasma cells interact with T cells through the intercellular adhesion mol-ecule 2-integrin-aLb2 complex,and then release interleukin 1 beta(IL1B),as verified by immunohistochemistry,ultimately promoting tumor growth.
Conclusion:Our results revealed the role of plasma cells in TNBC and identified IL1B as a new prognostic marker for TNBC.
机标关键词：interleukin-1environmentanalysiscancermicrothattumorbeta
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 617-625 )
英文信息