DOI: 10.1002/ame2.12464
Role of short-chain fatty acids in host physiology
Mingyue Liu1
Yubo Lu2
Guoyu Xue1
Le Han3
Hanbing Jia4
Zi Wang4
Jia Zhang5
Peng Liu6
Chaojuan Yang7
Yingjie Zhou8
1.Stem Cell Storage Center,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China2.School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai,China3.Prevention Health Section,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China4.Department of Medical Imaging,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China5.Department of Obstetrical,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China6.Department of Clinical Laboratory,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China7.Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Engineering Medicine,Beihang University,Beijing,China8.Department of Obstetrics and Gynecology,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China
摘要：Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health.As important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial infections.This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-lung axis,and promoting bone health.
机标关键词：physiologyrolehostacidsfattyshort-chain
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 641-652 )
英文信息