DOI: 10.1002/ame2.12477
An overview of different methods to establish a murine premature ovarian failure model
Negar Pouladvand1
Mahnaz Azarnia2
Hadis Zeinali2
Rouhollah Fathi3
Somayeh Tavana3
1.Department of Embryology,Reproductive Biomedicine Research Center,Royan Institute for Reproductive Biomedicine,ACECR,Tehran,Iran;Department of Animal Biology,Faculty of Biological Sciences,Kharazmi University,Tehran,Iran2.Department of Animal Biology,Faculty of Biological Sciences,Kharazmi University,Tehran,Iran3.Department of Embryology,Reproductive Biomedicine Research Center,Royan Institute for Reproductive Biomedicine,ACECR,Tehran,Iran
摘要：Premature ovarian failure(POF)is defined as the loss of normal ovarian function be-fore the age of 40 and is characterized by increased gonadotropin levels and decreased estradiol levels and ovarian reserve,often leading to infertility.The incomplete under-standing of the pathogenesis of POF is a major impediment to the development of effective treatments for this disease,so the use of animal models is a promising option for investigating and identifying the molecular mechanisms involved in POF patients and developing therapeutic agents.As mice and rats are the most commonly used models in animal research,this review article considers studies that used murine POF models.In this review based on the most recent studies,first,we introduce 10 differ-ent methods for inducing murine POF models,then we demonstrate the advantages and disadvantages of each one,and finally,we suggest the most practical method for inducing a POF model in these animals.This may help researchers find the method of creating a POF model that is most appropriate for their type of study and suits the purpose of their research.
机标关键词：overviewdifferentmodelestablishfailuremethodsmurineovarian
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 835-852 )
英文信息