DOI: 10.1002/ame2.12487
Animal models in neuroscience with alternative approaches:Evolutionary,biomedical,and ethical perspectives
Sabina Neziri1
Ahmet Efe Köseoğlu2
Gülsüm Deniz Köseoğlu3
Buminhan Özgültekin4
Nehir Özdemir Özgentürk1
1.Department of Molecular Biology and Genetics,Faculty of Art and Science,Yildiz Technical University,Istanbul,Turkey2.COMED Therapeutics,Malta Life Sciences Park,San Gwann,Malta3.Experimental Eye Research Institute,Ruhr University Bochum,Bochum,Germany4.Department of Biomedical Engineering,Faculty of Engineering and Natural Sciences,Acibadem University,Istanbul,Turkey
摘要：Animal models have been a crucial tool in neuroscience research for decades,pro-viding insights into the biomedical and evolutionary mechanisms of the nervous sys-tem,disease,and behavior.However,their use has raised concerns on several ethical,clinical,and scientific considerations.The welfare of animals and the 3R principles(replacement,reduction,refinement)are the focus of the ethical concerns,targeting the importance of reducing the stress and suffering of these models.Several laws and guidelines are applied and developed to protect animal rights during experimenting.Concurrently,in the clinic and biomedical fields,discussions on the relevance of ani-mal model findings on human organisms have increased.Latest data suggest that in a considerable amount of time the animal model results are not translatable in humans,costing time and money.Alternative methods,such as in vitro(cell culture,microscopy,organoids,and micro physiological systems)techniques and in silico(computational)modeling,have emerged as potential replacements for animal models,providing more accurate data in a minimized cost.By adopting alternative methods and promoting ethical considerations in research practices,we can achieve the 3R goals while uphold-ing our responsibility to both humans and other animals.Our goal is to present a thor-ough review of animal models used in neuroscience from the biomedical,evolutionary,and ethical perspectives.The novelty of this research lies in integrating diverse points of views to provide an understanding of the advantages and disadvantages of animal models in neuroscience and in discussing potential alternative methods.
机标关键词：alternativemodelswithanimalapproachesbiomedicalethicalevolutionary
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 868-880 )
英文信息