DOI: 10.1002/ame2.12417
Age-related changes in behavior profile in male offspring of rats treated with poly l:C-induced maternal immune activation in early gestation
Tengfei Chen1
Huadan Meng1
Ni Fang1
Peiling Shi1
Mengxue Chen1
Qing Liu1
Luxian Lv2
Wenqiang Li3
1.Henan Mental Hospital,The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,China;Henan Key Lab of Biological Psychiatry of Xinxiang Medical University,Xinxiang,China;International Joint Research Laboratory for Psychiatry and Neuroscience of Henan,Xinxiang,China2.Henan Mental Hospital,The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,China;Henan Key Lab of Biological Psychiatry of Xinxiang Medical University,Xinxiang,China;International Joint Research Laboratory for Psychiatry and Neuroscience of Henan,Xinxiang,China;Henan Province People's Hospital,Zhengzhou,Henan,China3.Henan Mental Hospital,The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,China;Henan Key Lab of Biological Psychiatry of Xinxiang Medical University,Xinxiang,China;International Joint Research Laboratory for Psychiatry and Neuroscience of Henan,Xinxiang,China;Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder,Xinxiang Medical University,Xinxiang,China
摘要：Background:Autism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy.It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system.
Methods:Sprague-Dawley rats received a single caudal vein injection of 10mg/kg polyinosinic:polycytidylic acid(poly I:C)on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood.
Results:Maternal serum levels of interleukin(IL)-6,IL-1β and tumor necrosis factor-αwere elevated in poly I:C-treated dams.The offspring of maternal poly I∶C-induced rats showed increased anxiety,impaired social approach,and progressive impaired cognitive and sensorimotor gating function.
Conclusion:Maternal immune activation led to developmental specificity behavioral impairment in offspring.
机标关键词：behaviorprofileratswithpolyactivationage-relatedc-induced
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 914-925 )
英文信息