DOI: 10.1002/ame2.12509
Unwanted disorders and xenogeneic graft-versus-host disease in experimental immunodeficient mice:How to evaluate and how to report
Seyed Mostafa Monzavi1
Samad Muhammadnejad2
Vahid Mansouri1
Hami Ashraf3
Naser Ahmadbeigi1
1.Gene Therapy Research Center,Digestive Diseases Research Institute,Tehran University of Medical Sciences,Tehran,Iran2.Gene Therapy Research Center,Digestive Diseases Research Institute,Tehran University of Medical Sciences,Tehran,Iran;INSERM U981,Institut Gustave Roussy,Villejuif,France3.Gene Therapy Research Center,Digestive Diseases Research Institute,Tehran University of Medical Sciences,Tehran,Iran;Chronic Respiratory Diseases Research Center,National Research Institute of Tuberculosis and Lung Diseases(NRITLD),Shahid Beheshti University of Medical Sciences,Tehran,Iran
摘要：Human-derived tumor models are essential for preclinical development of new anti-cancer drug entities.Generating animal models bearing tumors of human origin,such as patient-derived or cell line-derived xenograft tumors,is dependent on immuno-deficient strains.Tumor-bearing immunodeficient mice are susceptible to develop-ing unwanted disorders primarily irrelevant to the tumor nature;and if get involved with such disorders,reliability of the study results will be undermined,inevitably con-founding the research in general.Therefore,a rigorous health surveillance and clinical monitoring system,along with the establishment of a strictly controlled barrier facility to maintain a pathogen-free state,are mandatory.Even if all pathogen control and biosafety measures are followed,there are various noninfectious disorders capable of causing tissue and multiorgan damage in immunodeficient animals.Therefore,the re-searchers should be aware of sentinel signs to carefully monitor and impartially report them.This review discusses clinical signs of common unwanted disorders in experi-mental immunodeficient mice,and how to examine and report them.
机标关键词：reporthostmicediseasedisordersevaluateexperimentalgraft
论文发表日期：2025-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 20-29 )
英文信息