DOI: 10.1002/ame2.12385
Dyssynchronous heart failure models in canines:New insights into electrocardiographic,echocardiographic and histological features
Han Jin1
Shengwen Yang2
Hao Huang3
Sijing Cheng3
Pengkang He1
Sixian Weng3
Min Gu3
Hongxia Niu3
Wei Hua3
Yiran Hu4
Hui Li5
1.Cardiology Department,Peking University First Hospital,Beijing,China2.Department of Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing,China3.Cardiac Arrhythmia Center,Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China4.Cardiac Arrhythmia Center,Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Cardiology and Macrovascular Disease,Beijing Tiantan Hospital,Capital Medical University,Beijing,China5.Department of Ultrasound,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：Background:We investigated the similarities and differences between two experi-mental approaches using tachy-pacing technology to induce desynchronized heart failure in canines.
Methods:A total of eight dogs were included in the experiment,four were tachy-paced in right ventricle apex(RVAP)and 4 were paced in right atrium after the ablation of left bundle branch to achieve left bundle branch block(RAP+LBBB).Three weeks of follow-up were conducted to observe the changes in cardiac function and myocar-dial staining was performed at the end of the experiment.
Results:Both experimental approaches successfully established heart failure with reduced ejection fraction models,with similar trends in declining cardiac function.The RAP+LBBB group exhibited a prolonged overall ventricular activation time,de-layed left ventricular activation,and lesser impact on the right ventricle.The RVAP approach led to a reduction in overall right ventricular compliance and right ventricu-lar enlargement.The RAP+LBBB group exhibited significant reductions in left heart compliance(LVGLS,％:RAP+LBBB-12.60±0.12 to-5.93±1.25;RVAP-13.28±0.62 to-8.05±0.63,p=0.023;LASct,％:RAP+LBBB-15.75±6.85 to-1.50±1.00;RVAP-15.75±2.87 to-10.05±6.16,p=0.035).Histological examination revealed more pronounced fibrosis in the left ventricular wall and left atrium in the RAP+LBBB group while the RVAP group showed more prominent fibrosis in the right ventricular myocardium.
Conclusion:Both approaches establish HFrEF models with comparable trends.The RVAP group shows impaired right ventricular function,while the RAP+LBBB group exhibits more severe decreased compliance and fibrosis in left ventricle.
机标关键词：graphicinsightstrocarmodelsheartechocardardi
论文发表日期：2025-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 142-153 )
英文信息