DOI: 10.1002/ame2.12373
Causal relationship between lipid profile and muscle atrophy:A bi-directional Mendelian randomization study
Kun Chen1
Peng Gao1
Xiaoxiang Fang1
Kexing Tang1
Pan Ouyang1
Zongchao Li1
Liangjun Li1
Zhenhan Deng2
1.Department of Orthopaedics,The Affiliated Changsha Central Hospital,Hengyang Medical School,University of South China,Changsha,Hunan,China2.Department of Orthopaedic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China
摘要：Background:The aim of this study was to analyze the bi-directional causal relation-ship between lipid profile and characteristics related to muscle atrophy by using a bi-directional Mendelian randomization(MR)analysis.
Methods:The appendicular lean mass(ALM),whole body fat-free mass(WBFFM)and trunk fat-free mass(TFFM)were used as genome-wide association study(GWAS)data for evaluating muscle mass;the usual walking pace(UWP)and low grip strength(LGS)were used as GWAS data for evaluating muscle strength;and the triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL),low density lipo-protein cholesterol(LDL),apolipoprotein A-1(Apo A-1),and apolipoprotein B(Apo B)were used as GWAS data for evaluating lipid profile.For specific investigations,we mainly employed inverse variance weighting for causal estimation and MR-Egger for pleiotropy analysis.
Results:MR results showed that the lipid profile predicted by genetic variants was negatively correlated with muscle mass,positively correlated with UWP,and was not causally correlated with LGS.On the other hand,the muscle mass predicted by genetic variants was negatively correlated with lipid profile,the UWP predicted by genetic variants was mainly positively correlated with lipid profile,while the LGS pre-dicted by genetic variants had no relevant causal relationship with lipid profile.
Conclusions:Findings of this MR analysis suggest that hyperlipidemia may affect muscle mass and lead to muscle atrophy,but has no significant effect on muscle strength.On the other hand,increased muscle mass may reduce the incidence of dyslipidemia.
机标关键词：relationshipprofilebetweenstudyatrophybi-directionalcausallipid
论文发表日期：2025-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 154-161 )
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