DOI: 10.1002/ame2.12502
dP/dtmax:An underestimated prognostic factor in large animal infarction model
Rita Garamvölgyi1
Dénes Kőrösi1
Ottó Tátrai2
Emőke Bodor2
Dániel Fajtai3
Kornélia Farkas4
András Vorobcsuk5
1.Doctoral School in Animal Science,Hungarian University of Agriculture and Life Sciences,Kaposvár,Hungary2.Department of Cardiology,Kaposi Moritz Teaching Hospital,Kaposvár,Hungary3.Medicopus Nonprofit Ltd.,Kaposvár,Hungary4.Institute of Bioanalysis,Medical School,University of Pécs,Pécs,Hungary5.Department of Cardiology,Kaposi Moritz Teaching Hospital,Kaposvár,Hungary;Doctoral School of Clinical Medicine,University of Pécs,Pécs,Hungary
摘要：The present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes.A 90-min closed-chest bal-loon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in Pannon minipigs.To monitor the cardiac function,measurements were made by cardiac magnetic resonance imaging(cMRI),invasive pressure monitoring,and a Pulse index Continuous Cardiac Output(PiCCO)hemo-dynamic system at 0,72,and 720 h during the follow-up period.End-diastolic and end-systolic volumes(EDV,ESV),left ventricular ejection fraction(LVEF)obtained by cMRI evaluation,global ejection fraction and aortic dP/dtmax obtained by the invasive method,were recorded and compared.The 72-and 720-h EDV data showed a signifi-cant increase(p=0.012,＜0.001)compared to baseline,and the Day 30 data showed a significant increase compared to Day 3(p=0.022).The ESV 72 h after the infarction showed a significant increase(p=0.001)compared to baseline,which did not change significantly by Day 30(p=0.781)compared to Day 3.EDV and ESV were signifi-cantly negatively correlated with aortic dpmax,and ESV was significantly correlated with LVEF.For LVEF and dPmax,a significant(p＜0.001 and p=0.002)worsening was demonstrated at Day 3 compared to baseline,which was no longer statistically de-tectable for LVEF at Day 30(p=0.141),while the difference for dPmax was maintained(p=0.002).The complementary use of PiCCO hemodynamic measurements in large animal models makes the previously used methodologies more robust and reliable.
机标关键词：largemodelanimaldtmaxfactorinfarctionprognosticunderestimated
论文发表日期：2025-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 171-178 )
英文信息