DOI: 10.1002/ame2.12525
Polyphenols as Wnt/β-catenin pathway modulators:A promising strategy in clinical neurodegeneration
Biswajit Kumar Utpal1
Sajib Chandra Roy2
Mehrukh Zehravi3
Sherouk Hussein Sweilam4
A.Dinesh Raja5
M.Akiful Haque6
Chandan Nayak7
Senthilkumar Balakrishnan8
Laliteshwar Pratap Singh9
Saswati Panigrahi10
Mohammed Ali Alshehri11
Safia Obaidur Rab12
Najmus Sakib Minhaj2
Talha Bin Emran1
1.Department of Pharmacy,Faculty of Health and Life Sciences,Daffodil International University,Dhaka,Bangladesh2.Department of Pharmacy,Faculty of Pharmacy,University of Dhaka,Dhaka,Bangladesh3.Department of Clinical Pharmacy,College of Dentistry and Pharmacy,Buraydah Private Colleges,Buraydah,Saudi Arabia4.Department of Pharmacognosy,College of Pharmacy,Prince Sattam Bin Abdulaziz University,Al-Kharj,Saudi Arabia;Department of Pharmacognosy,Faculty of Pharmacy,Egyptian Russian University,Cairo,Egypt5.Department of Pharmaceutics,KMCH College of Pharmacy,Coimbatore,India6.Department of Pharmaceutical Analysis,School of Pharmacy,Anurag University,Hyderabad,India7.Department of Pharmaceutics,School of Pharmacy,Arka Jain University,Jharkhand,India8.Department of Pharmaceutics,JKKMMRF-Annai JKK Sampoorani Ammal College of Pharmacy,Komarapalayam,Namakkal,India9.Department of Pharmaceutical Chemistry,Narayan Institute of Pharmacy,Gopal Narayan Singh University,Sasaram,India10.Department of Pharmaceutical Chemistry,St.John Institute of Pharmacy and Research,Vevoor,Palghar,India11.Department of Biology,Faculty of Science,University of Tabuk,Tabuk,Saudi Arabia12.Department of Clinical Laboratory Sciences,College of Applied Medical Science,King Khalid University,Abha,Saudi Arabia
摘要：Polyphenols,a diverse group of naturally occurring compounds found in plants,have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases(NDs).The Wnt/β-catenin(Wβ C)signaling pathway,a crucial player in neurogenesis,neuronal survival,and synaptic plasticity,is involved in several cellular mechanisms related to NDs.Dysregulation of this pathway is a hallmark in the development of various NDs.This study explores multiple polyphenolic compounds,such as flavonoids,stilbenes,lignans,and phenolic acids,and their potential to protect the nervous system.It provides a comprehensive analysis of their effects on the Wβ C pathway,elucidating their modes of action.The study highlights the dual function of polyphenols in regulating and protecting the nervous system,providing reassurance about the research benefits.This review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research,shedding light on how these substances influence the various components of the pathway.The focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress,inflammation,and apoptotic processes,ultimately improving the function and survival of neurons.This study aims to offer a thorough understanding of the potential of polyphenols in targeting the Wβ C signaling pathway,which could lead to the development of innovative therapeutic options for NDs.
机标关键词：cateninstrategyclinicalneurodpathwaydegenerationmodulatorspolyphenols
论文发表日期：2025-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：21( 266-286 )
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