DOI: 10.1002/ame2.12528
Targeting intracellular autophagic process for the treatment of post-stroke ischemia/reperfusion injury
Jun Hu1
Zekai Hu2
Jiayi Xia2
Yeping Chen2
Dennis Cordato3
Qi Cheng3
Jie Wang1
1.Department of Traditional Rehabilitation,The Second Rehabilitation Hospital of Shanghai,Shanghai,China2.The Clinical Research Centre,The Second Rehabilitation Hospital of Shanghai,Shanghai,China3.Department of Neurology and Neurophysiology,Liverpool Hospital,Sydney,New South Wales,Australia;Stroke and Neurology Research Group,Ingham Institute for Applied Medical Research,Sydney,New South Wales,Australia
摘要：Cerebral ischemia/reperfusion(I/R)injury is an important pathophysiological condi-tion of ischemic stroke that involves a variety of physiological and pathological cell death pathways,including autophagy,apoptosis,necroptosis,and phagoptosis,among which autophagy is the most studied.We have reviewed studies published in the past 5years regarding the association between autophagy and cerebral I/R injury.To the best of our knowledge,this is the first review article summarizing potential candidates targeting autophagic pathways in the treatment of I/R injury post ischemic stroke.The findings of this review may help to better understand the pathogenesis and mecha-nisms of I/R events and bridge the gap between basic and translational research that may lead to the development of novel therapeutic approaches for I/R injury.
机标关键词：processischemiaautophagicinjuryintracellularpost-strokereperfusiontargeting
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 389-404 )
英文信息