DOI: 10.1002/ame2.12479
A comparative study of the established methods and evaluation of rat trauma models
Zhenmin Sun1
Jia Sun2
Gang Su2
Ruohan Wang2
Zhaohui Zhai2
Feng Yu3
Yuli Li4
1.Qingdao Hospital,University of Health and Rehabilitation Sciences,Qingdao Municipal Hospital,Qingdao,China;Shandong Second Medical University,Weifang,China2.Shandong Second Medical University,Weifang,China3.State Key Laboratory of Marine Resource Utilization in South China Sea,Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources,College of Materials Science and Engineering,Hainan University,Haikou,China4.Qingdao Hospital,University of Health and Rehabilitation Sciences,Qingdao Municipal Hospital,Qingdao,China
摘要：Background:Scientific animal models are indispensable for studying trauma repair.This work aimed at establishing a more scientific rat trauma model by studying dif-ferent rat trauma models caused by different trauma numbers,locations,and trauma attachment tension unloaders and rat age.
Methods:A four-trauma self-upper,lower,left and right control model;a two-trauma self-trauma bare and ring control model;and a young and old rat trauma model were created to evaluate the condition of these traumas.
Results:In the four-trauma self-control model,the healing status of the upper proximal cephalic trauma was better than that of the lower proximal caudal trauma,whereas there was no significant difference between the left and right trauma.The healing rate and postwound condition of the trauma with a ring control in the two-trauma model were better than those of the bare side.The healing speed of the old rats was slower,and the amount of extracellular matrix in the subcutaneous tissue after heal-ing was significantly lower than that of the young rats.
Conclusion:The double trauma with a ring is a more scientific and reasonable ex-perimental model.There is a significant difference between young and old rats in the wound healing process.Therefore,the appropriate age of the rats should be selected according to the main age range of the patients with similar conditions in the clinical setting being mimicked.
机标关键词：evaluationstudymodelscomparativeestablishedmethodstrauma
论文发表日期：2025-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 501-510 )
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