DOI: 10.1002/ame2.12568
System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice
Iqbal M.Lone1
Osayd Zohud1
Kareem Midlej1
Charles Brenner2
Fuad A.Iraqi1
1.Department of Clinical Microbiology and Immunology,Faculty of Medicine and Health Sciences,Tel Aviv University,Tel-Aviv,Israel2.Department of Diabetes and Cancer Metabolism,Beckman Research Institute,Duarte,California,USA
摘要：It is increasingly recognized that young,chow-fed inbred mice poorly model the com-plexity of human carcinogenesis.In humans,age and adiposity are major risk factors for malignancies,but most genetically engineered mouse models(GEMM)induce car-cinogenesis too rapidly to study these influences.Standard strains,such as C57BL/6,commonly used in GEMMs,further limit the exploration of aging and metabolic health effects.A similar challenge arises in modeling periodontitis,a disease influenced by aging,diabesity,and genetic architecture.We propose using diverse mouse popula-tions with hybrid vigor,such as the Collaborative Cross(CC)×Apc Min hybrid,to slow disease progression and better model human colorectal cancer(CRC)and comorbidi-ties.This perspective highlights the advantages of this model,where delayed car-cinogenesis reveals interactions with aging and adiposity.Unlike Apc Min mice,which develop cancer rapidly,CC×Apc Min hybrids recapitulate human-like progression.This facilitates the identification of modifier loci affecting inflammation,diet susceptibility,organ size,and polyposis distribution.The CC×Apc Min model offers a transformative platform for studying CRC as a disease of adulthood,reflecting its complex inter-play with aging and comorbidities.The insights gained from this approach will en-hance early detection,management,and treatment strategies for CRC and related conditions.
机标关键词：developmentgeneticanalysiscancersystemmiceagingcollaborative
论文发表日期：2025-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 758-770 )
英文信息