DOI: 10.1002/ame2.12551
Targeting signaling pathways in neurodegenerative diseases:Quercetin's cellular and molecular mechanisms for neuroprotection
Rezaul Islam1
Ibrahim Khalil Al-Imran1
Mehrukh Zehravi2
Sherouk Hussein Sweilam3
Mohammad Rakib Mortuza4
Jeetendra Kumar Gupta5
Thukani Sathanantham Shanmugarajan6
Kadirvel Devi6
Tanuja Tummala7
Mohammed Ali Alshehri8
Kalirajan Rajagopal9
Mohammed Asiri10
Irfan Ahmad10
Talha Bin Emran1
1.Department of Pharmacy,Faculty of Health and Life Sciences,Daffodil International University,Daffodil Smart City,Bangladesh2.Department of Clinical Pharmacy,College of Dentistry and Pharmacy,Buraydah Private Colleges,Buraydah,Saudi Arabia3.Department of Pharmacognosy,College of Pharmacy,Prince Sattam Bin Abdulaziz University,Al-Kharj,Saudi Arabia;Department of Pharmacognosy,Faculty of Pharmacy,Egyptian Russian University,Cairo,Egypt4.Department of Chemistry and Biochemistry,Lamar University,Beaumont,Texas,USA5.Department of Pharmacology,Institute of Pharmaceutical Research,GLA University,Mathura,India6.Department of Pharmaceutics,School of Pharmaceutical Sciences,Vels Institute of Science,Technology and Advanced Studies(VISTAS),Chennai,India7.Department of Polymer Chemistry,Pittsburg State University,Pittsburg,Kansas,USA8.Department of Biology,Faculty of Science,University of Tabuk,Tabuk,Saudi Arabia9.Department of Pharmaceutical Chemistry,JSS College of Pharmacy,JSS Academy of Higher Education and Research,Ooty,India10.Department of Clinical Laboratory Sciences,College of Applied Medical Science,King Khalid University,Abha,Saudi Arabia
摘要：Background:Neurodegenerative diseases(NDs),including Alzheimer's disease,Parkinson's disease,and Huntington's disease,are complex and challenging due to their intricate pathophysiology and limited treatment options.
Methods:This review systematically sourced articles related to neurodegenerative diseases,neurodegeneration,quercetin,and clinical studies from primary medical da-tabases,including Scopus,PubMed,and Web of Science.
Results:Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration.Quercetin,a flavonoid abundant in vegeta-bles and fruits,is gaining attention for its antioxidant,anti-inflammatory,and antia-poptotic properties.It regulates signaling pathways such as nuclear factor-KB(NF-κB),sirtuins,and phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt).These path-ways are essential for cellular survival,inflammation regulation,and apoptosis.Preclinical and clinical studies have shown that quercetin improves symptoms and pathology in neurodegenerative models,indicating promising outcomes.
Conclusions:The study explores the potential of incorporating laboratory research into practical medical treatment,focusing on quercetin's neuroprotective effects on NDs and its optimal dosage.
机标关键词：quercetinmolecularpathwaysneurodcellulardegenerativediseasesmechanisms
论文发表日期：2025-03-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：21( 798-818 )
英文信息