DOI: 10.1002/ame2.12573
Progress in research on osteoporosis secondary to SARS-CoV-2 infection
Jinlong Wang1
Yibai Xiong2
Zhiqi Song2
Yanhong Li2
Ling Zhang2
Chuan Qin1
1.Institute of Laboratory Animal Sciences,CAMS and Comparative Medicine Center,PUMC,Beijing,China;Changping National Laboratory(CPNL),Beijing,China2.Institute of Laboratory Animal Sciences,CAMS and Comparative Medicine Center,PUMC,Beijing,China
摘要：The World Health Organization has declared that COVID-19 no longer constitutes a"public health emergency of international concern,"yet the long-term impact of SARS-CoV-2 infection on bone health continues to pose new challenges for global public health.In recent years,numerous animal model and clinical studies have revealed that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can lead to secondary osteoporosis.The mechanisms involved are related to the virus's direct effects on bone tissue,dysregulation of the body's inflammatory response,hypoxia,noncoding RNA imbalance,and metabolic abnormalities.Although these studies have unveiled the connection between SARS-CoV-2 infection and osteoporosis,current research is not comprehensive and in depth.Future studies are needed to evaluate the long-term effects of SARS-CoV-2 on bone density and metabolism,elucidate the specific mechanisms of pathogenesis,and explore potential interventions.This review aims to collate existing research literature on SARS-CoV-2 infection-induced second-ary osteoporosis,summarize the underlying mechanisms,and provide direction for future research.
机标关键词：sars-cov-2secondaryresearchinfectionosteoporosisprogress
论文发表日期：2025-03-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 829-841 )
英文信息