DOI: 10.1002/ame2.70001
Description of unilateral kidney embolism and contralateral nephrectomy as a less invasive remnant kidney model in cats;a proof-of-concept study
Chad W.Schmiedt1
Bianca N.Lourenço1
Lauren E.Markovic1
Meghan Lancaster1
Sanjeev Gumber2
Juliane Wannemacher2
Peter Florian2
Amanda E.Coleman1
1.Department of Small Animal Medicine and Surgery,College of Veterinary Medicine,University of Georgia,Athens,Georgia,USA2.Boehringer Ingelheim Vetmedica GmbH,Ingelheim am Rhein,Germany
摘要：Background:Refined models of kidney disease are critical to better understand dis-ease processes and study novel treatments while minimizing discomfort in research animals.The objective of this study was to report a technique for minimally invasive partial kidney embolism in cats and describe outcomes following transcatheter ad-ministration of embolic microspheres with subsequent contralateral nephrectomy.
Methods:Eleven,apparently healthy,male,purpose-bred cats underwent unilateral kidney embolism with 0.25 or 0.5mL of embolic microparticle(40-120μm)suspen-sion(0.2 mL microspheres/mL)delivered into the right renal artery under fluoroscopic guidance,followed 5 months later by contralateral nephrectomy.One month after ne-phrectomy,blood and urinary markers of kidney function were evaluated,and embo-lized kidneys were harvested for histopathology evaluation.
Results:Renal artery embolization was possible in all cats.Two cats did not complete the study,one after experiencing congestive heart failure(n=1)and the other fol-lowing evidence of complete kidney embolism precluding nephrectomy(n=1)post-embolization.At study end,compared to baseline,cats had significant increases in median(range)serum creatinine(159.1 μmol/L[141.4-530.4]versus 128.2 μmol/L[92.8-150.3];p=0.0004),urea nitrogen(15.71 mmol/L[9.29-47.85]versus 7.50mmol/L[6.07-8.57];p＜0.0001),and symmetric dimethylarginine(0.74μmol/L[0.59-3.12]versus 0.67μmol/L[0.54-0.72];p=0.0288)concentrations.No differ-ences in markers of kidney function were documented between dose groups.
Conclusions:Minimally invasive kidney embolism is a promising technique for mod-eling kidney disease in cats.Understanding optimal dose,timing of nephrectomy,and longer-term consequences requires additional work.
机标关键词：kidneyconceptstudymodelcatslesscontralateraldescription
论文发表日期：2025-03-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 886-895 )
英文信息