DOI: 10.1002/ame2.70003
Antibacterial effects of lidocaine and saline irrigation on Escherichia coli in superficial surgical wounds
David Ramírez-Tapia1
José A.Ortega-Salgado2
Stephania Rámirez-Guzmán3
Jorge Lopez-Lopez1
Alejandro Rodríguez-Baéz4
Natalia Nuño-Lámbarri5
Eduardo E.Montalvo-Javé6
1.Hepato Pancreato and Biliary Clinic,Department of General Surgery,"Hospital General de Mexico",Dr.Eduardo Liceaga,Mexico City,Mexico2.Department of Surgery,Faculty of Medicine,The National Autonomous University of Mexico(UNAM),Mexico City,Mexico;Pediatric Surgery Service,Centro Médico Nacional"20 de Noviembre"ISSSTE,Mexico City,Mexico3.Emergency Unit,"Hospital General de Mexico",Dr.Eduardo Liceaga,Mexico City,Mexico4.Hepato Pancreato and Biliary Clinic,Department of General Surgery,"Hospital General de Mexico",Dr.Eduardo Liceaga,Mexico City,Mexico;Department of Surgery,Faculty of Medicine,The National Autonomous University of Mexico(UNAM),Mexico City,Mexico5.Department of Surgery,Faculty of Medicine,The National Autonomous University of Mexico(UNAM),Mexico City,Mexico;Traslational Research Unit,Medica Sur Clinic & Foundation,Mexico City,Mexico6.Hepato Pancreato and Biliary Clinic,Department of General Surgery,"Hospital General de Mexico",Dr.Eduardo Liceaga,Mexico City,Mexico;Department of Surgery,Faculty of Medicine,The National Autonomous University of Mexico(UNAM),Mexico City,Mexico;Obesity and Digestive Diseases Unit,Medica Sur Clinic & Foundation,Mexico City,Mexico
摘要：This study evaluated the antibacterial effects of 2％lidocaine and its combination with 0.9％saline solution on Escherichia coli infection in superficial surgical wounds in Wistar rats.The goal was to determine if these treatments could effectively reduce E.coli Colony Forming Units(CFUs)below the critical threshold of 1×105.Seventy male Wistar rats were divided into seven groups,each undergoing different interventions to assess the antibacterial efficacy of lidocaine,with outcomes measured through bacterial cultures and CFU quantification.Results demonstrated a Log10 reduction of approximately 0.44 in E.coli CFUs following infiltration with 2％lidocaine.The combined use of 2％lidocaine infiltration and 0.9％saline irrigation resulted in nearly complete suppression of bacterial growth.These findings suggest that these simple interventions could be valuable in emergency surgical settings to mitigate the risk of surgical site infections and serve as effective prophylactic measures.
机标关键词：antibacterialirrigationcolieffectsescherichialidocainesalinesuperficial
论文发表日期：2025-03-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 939-943 )
英文信息