DOI: 10.1002/ame2.12548
Animal models of cisplatin-induced neuropathic pain
Ningxin Li1
Mingzhu Li2
Shengbo Jin3
Jun Yu3
Hongzhe Wei1
Wenping Wang2
Siyao Ma2
Yuxin Jiang3
Qian Liu3
Huini Yao1
1.China Medical University,Shenyang,China2.Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute,Sheng Yang,China3.Liaoning University of Traditional Chinese Medicine,Shenyang,China
摘要：Cisplatin chemotherapy has been used as the main treatment for different types of can-cer.However,cisplatin chemotherapy-induced peripheral neuropathic pain(CIPNP)seri-ously affects the treatment process and quality of life of patients.In addition,it impacts the underlying mechanism and prevention and treatment strategies,indicating that drug selection and efficacy evaluation need to be further investigated.Furthermore,an animal model that is more consistent with the pathological mechanism needs to be developed.In this study,we describe and discuss the methods of developing and detecting CIPNP models in rats and mice induced by cisplatin chemotherapy.The aim was to improve the modeling rate and develop animal models that are more consistent with the developmen-tal pattern of the disease.In addition,the study provides ideal reference animal models for clinical research and drug discovery and development.
机标关键词：cisplatinmodelsanimalinducedneuropathicpain
论文发表日期：2025-07-30
在线出版日期：2025-09-28（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1206-1214 )
英文信息