DOI: 10.1002/ame2.70028
Animal models of lung cancer:Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms
Zixuan Yang1
Xianbin Zhao1
Lili Tan2
Pingxinyi Que2
Tong Zhao2
Wei Huang3
Dejiao Yao4
Songqi Tang1
1.School of Traditional Chinese Medicine,Hainan Medical University,Haikou,China2.School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,China3.School of Basic Medical Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu,China4.Oncology Department Ⅱ,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,China
摘要：Lung cancer has one of the highest rates of incidence and mortality worldwide,mak-ing research on its mechanisms and treatments crucial.Animal models are essential in lung cancer research as they accurately replicate the biological characteristics and treatment outcomes seen in human diseases.Currently,various lung cancer models have been established,including chemical induction models,orthotopic transplan-tation models,ectopic transplantation models,metastasis models,and gene editing mouse models.Additionally,lung cancer grafts can be categorized into two types:tissue-based and cell-based grafts.This paper summarizes the phenotypes,advan-tages,and disadvantages of various induction methods based on their modeling tech-niques.The goal is to enhance the simulation of clinical lung cancer characteristics and to establish a solid foundation for future clinical research.
机标关键词：applicationdifferentcancermodelsstudyanimalcomparisonlung
论文发表日期：2025-07-30
在线出版日期：2025-09-28（本平台首次上网日期，不代表文献的发表时间）
页数：24( 1229-1252 )
英文信息