DOI: 10.1002/ame2.70024
Influence of the arterial elastic component on the response to balloon angioplasty in femoral arteries of a healthy porcine model
María Gracia de Garnica García1
Marina Gil Bernabé2
Claudia Pérez-Martínez2
Laura Mola Solà3
Luis Duocastella Codina3
María Molina Crisol3
Alex Gómez Castel3
Armando Pérez de Prado4
1.Department of Animal Health,Section of Pathology,Veterinary School,University of León,León,Spain;Micros Veterinaria S.L.,León,Spain2.Department of Animal Health,Section of Pathology,Veterinary School,University of León,León,Spain3.iVascular,Barcelona,Spain4.Complejo Asistencial Universitario de León,León,Spain
摘要：Background:The efficacy of balloon angioplasty for treating peripheral artery dis-ease is influenced by various factors,some of them not yet totally understood.This study aimed to evaluate the role of elastin content in vascular responses 28 days post-angioplasty using uncoated and paclitaxel-coated balloons with the same platform in femoral arteries of a healthy porcine model.
Methods:Eight animals underwent balloon angioplasty on the external and internal branches of femoral arteries.Histopathologic evaluation was conducted at follow-up to assess the elastin content,vascular damage,morphological features,and neointi-mal formation.
Results:The elastin content was significantly higher in the external than in the in-ternal femoral artery(p=0.0014).After balloon angioplasty,it was inversely corre-lated with vascular injury score(ρ=-0.4510,p=0.0096),neointimal inflammation(ρ=-0.3352,p=0.0607),transmural(ρ=-0.4474,p=0.0103)and circumferen-tial(ρ=-0.4591,p=0.0082)smooth muscle cell loss,presence of proteoglycans(ρ=-0.5172,p=0.0024),fibrin deposition(ρ=-0.3496,p=0.0499),and adventitial fibrosis(ρ=-0.6229,p=0.0002).Neointimal formation inhibition with paclitaxel was evident only in arteries with disruption of the internal elastic lamina,with a significant smaller neointimal area in arteries treated with paclitaxel-coated balloons compared to uncoated balloons(median[Q1-Q3]:10.25[7.49-15.64]vs.24.44[18.96-30.52],p=0.0434).
Conclusions:Elastin content varies between branches of the femoral artery and sig-nificantly influences the integrity of the internal elastic lamina,the vessel's adaptive response,and paclitaxel efficacy after balloon angioplasty.
机标关键词：angioplastycomponentmodelarterialarteriesballoonelasticfemoral
论文发表日期：2025-08-30
在线出版日期：2025-11-05（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1503-1512 )
英文信息