DOI: 10.1002/ame2.70050
Multiple low dose streptozotocin-induced diabetes as a model for studying autoimmune diabetes in humans
Ivan Koprivica
Suzana Stanisavljević
Dragica Mićanović
Ivana Stojanović
Đorđe Miljković
Department of Immunology,Institute for Biological Research"Siniša Stanković"-National Institute of Republic of Serbia,University of Belgrade,Belgrade,Serbia
摘要：The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 diabetes(T1D)in humans.Spontaneous animal mod-els of T1D greatly contribute to our understanding of the disease pathogenesis and therapeutic options.Amongst many disease models,a significant proportion of T1D research is performed on multiple low dose streptozotocin induced diabetes in experi-mental animals,in parallel.Here,we discuss advantages of this model for contempo-rary T1D research.Additionally,challenges and perspectives for further improvement of the model are presented.
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论文发表日期：2025-09-30
在线出版日期：2025-10-28（本平台首次上网日期，不代表文献的发表时间）
页数：13( 1539-1551 )
英文信息