DOI: 10.1002/ame2.70023
Neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios as inflammatory markers in the assessment of glycemic status in diabetic patients of Asir region
Ayed A.Dera1
Abeer Abdullah Alghamdi1
Mesfer Al-Shahrani1
Reem M.Al-Gahtani1
Bashayer Saad Alghamdi2
Gaffar Sarwar Zaman1
Mohammed Abdul Rasheed3
Hassan Al-Shehri4
Lana Al-qhtani1
Syed Parween Ali1
Umme Hani5
Talha Bin Emran6
1.Department of Clinical Laboratory Sciences,College of Applied Medical Sciences,King Khalid University,Abha,Saudi Arabia2.Department of Medical Laboratory,King Faisal Medical Complex,Taif,Saudi Arabia3.Department of Pathology,Dr.VRK Women's Medical College,Hyderabad,India4.Asir Central Hospital,Ministry of Health,Abha,Saudi Arabia5.Department of Pharmaceutics,College of Pharmacy,King Khalid University,Abha,Saudi Arabia6.Department of Pharmacy,Faculty of Allied Health Sciences,Daffodil International University,Dhaka,Bangladesh
摘要：Background:Diabetes mellitus(DM)is a prevalent chronic metabolic condition char-acterized by high blood sugar levels,resulting from insufficient insulin production or ineffective insulin use,posing substantial global health issues.Research on the rela-tionship between glycemic status and the ratio of neutrophils to lymphocytes(NLR)and monocytes to lymphocytes(MLR)is limited.This study aimed to fill these knowl-edge gaps by examining the connection between DM and inflammatory markers within the Asir region.
Methods:Data from 3545 participants were retrospectively analyzed.The dataset,gathered between 2021 and 2023,comprises 38 laboratory tests obtained from the Future Lab Pioneer database.The study's inclusion criteria focused on diabetes pro-file tests(glycated hemoglobin[HbA1c]and fasting blood glucose[FBG])and manu-ally computed inflammatory markers(NLR and MLR),which were stratified by age and sex.
Results:This study demonstrated significant differences in NLR levels compared with FBG levels across all adult age groups and adult female participants(p<0.0001),as well as among all elderly age groups(p=0.0006)and elderly women(p=0.01).MLR levels were significant in all adult age groups(p=0.04)and in adult women(p=0.02).When NLR and MLR were compared to HbA1c levels,a significant difference in the mean NLR was found in adult women(p=0.005).Additionally,the mean MLR levels were significant in all adult age groups(p=0.04)and adult women(p=0.02).
Conclusion:Although a larger sample size is necessary for this research,the results indicate that NLR and MLR could serve as valuable indicators for evaluating inflam-mation in people with disrupted glucose metabolism,particularly in adult and female populations.
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论文发表日期：2025-09-30
在线出版日期：2025-10-28（本平台首次上网日期，不代表文献的发表时间）
页数：12( 1567-1578 )
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