DOI: 10.1002/ame2.70067
Brief introduction in phenotypic and genetic differences of C57BL/6 and BALB/c mice substrains
Lan Zhao
Jie Wei
Bingfei Yue
Division of Laboratory Animal Monitoring,National Institutes for Food and Drug Control,Beijing,China;China National Rodent Laboratory Animal Resources Center,Beijing,China
摘要：Experimental mice play a critical role in biomedical research.The phenotype and ap-plication of different substrains vary due to genetic differentiation and variation.To ensure validity and reliability of results,it is imperative to adhere to standardized ex-periments and controls.This paper objectively reviews the origin,differentiation,and phenotypic and genetic differences between the C57BL/6 and BALB/c mouse sub-strains.Furthermore,an optimal selection strategy is proposed based on the genetic quality control technology to facilitate the precise application of these two mouse substrains.
机标关键词：
论文发表日期：2025-09-30
在线出版日期：2025-10-28（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1628-1634 )
英文信息