DOI: 10.1002/ame2.70022
Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw-Rod external fixation
Mohammad Mahdi Gooran1
Ramin Mazaheri-Khameneh1
Seyed Mohammad Hashemi-Asl1
Rahim Hobbenaghi2
1.Department of Surgery and Diagnostic Imaging,Faculty of Veterinary Medicine,Urmia University,Urmia,Iran2.Department of Pathobiology,Faculty of Veterinary Medicine,Urmia University,Urmia,Iran
摘要：Background:Biological osteosynthesis preserves blood supply and promotes rapid healing by aligning fracture fragments without direct surgical exposure.Pedicle screws are primarily designed for internal fixation in spinal procedures.A key objec-tive of many orthopedic studies is to assess the biocompatibility of implants with bone and adjacent soft tissue.This study aims to evaluate the biocompatibility and effects of the Pedicle screw-Rod configuration as a novel external fixation method in canine tibial osteotomy.
Methods:With ethics approval,eight healthy,intact male dogs,aged 10-12 months and weighing between 20 and 22 kg,underwent a minimally invasive medial tibial approach for surgical fixation of tibial osteotomy using a Pedicle screw-Rod configu-ration.Postoperative evaluations included ultrasound assessments at the osteotomy site and histological evaluations at the bone-screw interface.
Results:B-mode ultrasound evaluation indicated healing progress at all osteotomy sites.The color Doppler examination revealed an initial increase in signals in the sur-rounding soft tissue during the first 4weeks post-operation,followed by a decrease in signals within the adjacent soft tissue between the 5th and 8th weeks.During this latter period,the signals were primarily concentrated on the bone surface and the callus.The bone-screw interface at various screw sites exhibited similar histological changes,indicating effective integration of the newly formed woven bone into the screw threads.
Conclusions:Fixation of non-articular tibial osteotomy with Pedicle screw-Rod con-figuration resulted in secondary bone healing,characterized by abundant callus for-mation and neovascularization.This implant demonstrated favorable biocompatibility with bone and surrounding soft tissue,without significant complications.
机标关键词：compatibilityiocompcanineexperimentallyexternalfixationfractureshealing
论文发表日期：2026-01-30
在线出版日期：2026-03-27（本平台首次上网日期，不代表文献的发表时间）
页数：10( 31-40 )
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