DOI: 10.1002/ame2.70115
Recent advances in animal models for pathological scar research:A comprehensive review of experimental approaches and translational relevance
Diana-Larisa Ancuța1
Mariana Vǎduva1
Cristin Coman2
Iuliana Cara1
1."Cantacuzino"National Military-Medical Institute for Research and Development,Bucharest,Romania2."Cantacuzino"National Military-Medical Institute for Research and Development,Bucharest,Romania;Faculty of Veterinary Medicine,University of Agronomic Sciences and Veterinary Medicine,Bucharest,Romania;Center of Excellence in Translational Medicine,Fundeni Clinical Institute,Bucharest,Romania
摘要：Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
机标关键词：researchreviewscarmodelsadvancesanimalapproachescomprehensive
论文发表日期：2026-01-30
在线出版日期：2026-03-27（本平台首次上网日期，不代表文献的发表时间）
页数：13( 59-71 )
英文信息