DOI: 10.1002/ame2.70127
The OtR tumor recurrence and metastasis model reveals doxorubicin-induced tumor shrinkage doesn't guarantee prolonged survival
Lingli Luo1
Ling Liu2
Minyao Deng2
Yong Jiang2
Chuan Liu3
Xiang Chen4
Xiaoxi Li2
1.Department of Infection Prevention and Control,Jiangxi Chest Hospital(Jiangxi Third People's Hospital),The Third Affiliated Hospital of Nanchang Medical College,Nanchang,China;Department of Laboratory Medicine,School of Medicine,Jiangsu University,Zhenjiang,China2.Department of Laboratory Medicine,School of Medicine,Jiangsu University,Zhenjiang,China3.Department of Oncology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China4.Department of Thyroid Breast Surgery,The Affiliated Yixing Hospital,of Jiangsu University,Wuxi,Jiangsu,China
摘要：Background:In preclinical research,tumor growth inhibition in subcutaneous models is frequently employed to evaluate therapeutic efficacy;however,such models often lack clinical translatability.
Methods:To better approximate clinical reality,taking the case of doxorubicin treatment,we utilized an orthotopic transplant and resection(OtR)strategy to systematically assess the effects of neoadjuvant chemotherapy,adjuvant chem-otherapy,and their combination on tumor growth,recurrence,and malignant progression.
Results:Surprisingly,none of the treatments improved mouse survival,with adjuvant therapy even shortening it.Although neoadjuvant chemotherapy delayed preopera-tive tumor growth,and all regimens reduced recurrence rates,none effectively pre-vented metastasis.Furthermore,all treatment groups exhibited weight loss,indicative of chemotherapy-induced cachexia.
Conclusions:Collectively,these findings demonstrate that reduced tumor growth in preclinical mouse models does not necessarily translate into overall survival benefit.Our results emphasize the critical importance of prioritizing metastasis prevention over tumor growth inhibition as a key efficacy endpoint in antitumor drug evaluation.
机标关键词：shrinkagetumormodeldoesndoxorubicinguaranteeinducedmetastasis
论文发表日期：2026-01-30
在线出版日期：2026-03-27（本平台首次上网日期，不代表文献的发表时间）
页数：8( 207-214 )
英文信息